Intercellular Adhesion Molecule-5 Induces Dendritic Outgrowth by Homophilic Adhesion

Intercellular Adhesion Molecule-5 Induces Dendritic Outgrowth by Homophilic Adhesion

Intercellular adhesion molecule-5 (ICAM-5) is a dendritically polarized membrane glycoprotein in telencephalic neurons, which shows heterophilic binding to leukocyte beta(2)-integrins. Here, we show that the human ICAM-5 protein interacts in a homophilic manner through the binding of the immunoglobulin domain 1 to domains 4-5. Surface coated ICAM-5-Fc promoted dendritic outgrowth and arborizati...

Urea induces intercellular adhesion molecule-1 expression

Background The dramatically increased cardiovascular risk in patients with chronic renal disease cannot be explained entirely by traditional cardiovascular risk factors. The continuous exposure of renal patients to elevated levels of urea may contribute to increased inflammation and oxidative stress. While urea may not be directly toxic, many molecules can be carbamylated through cyanate, a rea...

Hematopoietic / Endothelial Homophilic Adhesion Molecule

http://bloodjournal.hematologylibrary.org/content/92/12/4602.full.html Updated information and services can be found at: (3094 articles) Hematopoiesis and Stem Cells • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety ma...

Soluble Intercellular Adhesion Molecule

Previous studies have suggested that intercellular ad¬ hesion molecule 1 (ICAM-1, CD54) may be involved in the pathogenesis ofasthma. In addition, a soluble form of ICAM-1 (sICAM-1) has been detected in increased concentrations in the sera of patients with certain in¬ flammatory conditions. To determine whether bron¬ chial asthma is associated with increased levels of sICAM-1 in serum and to as...

Intercellular Adhesion Molecule (ICAM)-1,